Born in Barranquilla, Colombia in 1953, Mazzanti studied architecture at the Universidad Javeriana de Bogotá (1987) and earned a postgraduate degree in History and Theory of Architecture and Industrial Design at the University of Florence, Italy (1991). He has taught in prestigious Colombian universities and been guest professor in universities in the United States, Mexico, Argentina, Peru, and Panama.
His architecture covers a wide range of programs, including convention centers, libraries, schools, parks, pedestrian bridges, and private and collective housing. His recent works include the restaurant Nazca, the residential buildings Habitar 72 and Habitar 74, and several public daycare centers in Bogotá; the Biblioteca España library in Santo Domingo Savia and the León de Grieff Library Park, both in Medellín; and the district educational center in Lithuania. He is currently building the Colosseum of Medellín.
Winner of several Colombian competitions for the construction of public buildings, in 2006 he capped first prize in the Urban Design and Landscape category of the 10th Venice Biennale of Architecture awards, and in 2008 he won the award for Best Work at the 6th Ibero-American Biennial of Architecture and Urban Planning.